The recommended starting dose of Juxtapid is 5 mg once daily.
- The dose should be escalated gradually based on acceptable safety and tolerability.
- Transaminases should be measured prior to any increase in dose.
- The maintenance dose should be individualized, taking into account patient characteristics such as goal of therapy and response to treatment to a maximum of 60 mg daily as per the table below.
Recommended Regimen for Titrating Dosage
The table below shows the recommeded regimen for titrating dosage of Juxtapid.
|Dosage||Duration of Administration Before Considering Increase To Next Dosage|
|5mg daily||At least 2 weeks|
|10mg daily||At least 4 weeks|
|20mg daily||At least 4 weeks|
|40mg daily||At least 4 weeks|
Maximum recomended dosage
Juxtapid should be taken in the evening, with a glass of water, without food, and at least 2 hours after dinner. Administration with food may increase the risk of gastrointestinal adverse reactions. Patients should swallow Juxtapid capsules whole.
Administration of Juxtapid and bile acid sequestrants should be separated by at least 4 hours since bile acid sequestrants can interfere with the absorption of oral medications.
Because of Juxtapid’s mechanism of action in the small intestine, fat-soluble vitamins/fatty acids may not be properly absorbed. Patients on Juxtapid should take daily supplements containing 400 IU vitamin E and at least 200 mg linoleic acid, 210 mg alpha-linoleic acid (ALA), 110 mg eicosapentaenoic acid (EPA), and 80 mg docosahexaenoic acid (DHA).
Dosing modifications are recommended for patients taking concomitant CYP3A4 inhibitors, renal impairment, or baseline hepatic impairment. Dosing adjustments are also required for patients who develop transaminases values ≥3x the upper limit of normal (ULN) during treatment with Juxtapid. Learn more here. Click the tabs below for recommended dosing modifications.